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AHRQ's Healthcare-Associated Infections Program

Healthcare-associated infections (HAIs) are among the leading threats to patient safety, affecting one out of every 31 hospital patients at any one time. Over a million HAIs occur across the U.S. health care system every year, leading to the loss of tens of thousands of lives and adding billions of dollars to health care costs.

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AHRQ's HAI program funds work to help frontline clinicians and other health care staff prevent HAIs by improving how care is actually delivered to patients. This work is accomplished through a robust portfolio of grants and contracts that focus on applied research—or research that advances the ability of clinicians in the field to combat HAIs. This kind of research brings knowledge to the front lines of care faster by helping clinicians and staff better understand how to apply proven methods of making care safer. ÂÜÀòÊÓƵfunds both research and implementation projects that:

  • Advance the science of HAI prevention.
  • Develop more effective approaches for reducing HAIs.
  • Help clinicians apply proven methods to prevent HAIs.

ÂÜÀòÊÓƵconducts its HAI program in accordance with the framework established by the Department of Health and Human Services' (HHS) and the research agenda of the . Learn more about the .

These publicly-available tools and resources are based on AHRQ's research.

Tools & Resources to Prevent HAIs

Tools

CUSP

CUSP LogoThe Comprehensive Unit-based Safety Program (CUSP) combines techniques to improve safety culture, teamwork, and communications, together with a checklist of proven practices. The Core CUSP Toolkit was developed based on the experiences of more than 1,000 ICUs that reduced central line-associated blood stream infections by 41 percent. Visit the CUSP Method for more information.

  • Core CUSP Toolkit

    The Core CUSP Toolkit helps clinical teams develop a basic understanding of how to apply the CUSP method to make health care safer. Topic-specific toolkits provide additional resources that can help clinician teams address targeted safety issues within the CUSP framework.

  • MRSA Prevention Toolkit: Targeting SSI

    This toolkit provides the resources and tools to help tackle the complex problems of methicillin-resistant Staphylococcus aureus and surgical site infection prevention for surgical services, specifically cardiac, hip and knee joint replacement, and spinal fusion surgeries.
     
  • MRSA Prevention Toolkit: ICUs & Non-ICUs
     
    This toolkit equips healthcare professionals with the essential knowledge, resources, and tools to tackle prevention of methicillin-resistant Staphylococcus aureus (MRSA) in hospital intensive care units and non-intensive care units.  
     
  • Toolkit for Improving Surgical Care and Recovery 

    This toolkit helps hospitals implement evidence-based practices to improve outcomes and prevent complications among patients who undergo surgery. 
     

  • Toolkits To Improve Antibiotic Use

    Three toolkits that help hospitals, long-term care facilities, and ambulatory practices apply the Four Moments of Antibiotic Decision Making to improve antibiotic use.

  • Toolkit for Preventing CLABSI and CAUTI in ICUs

    This toolkit provides the clinical and cultural guidance to help hospital intensive care units (ICUs) make changes needed to decrease rates of central line-associated blood stream infection (CLABSI) and catheter-associated urinary tract infection (CAUTI). Using CUSP and other evidence-based practices, the toolkit helps ICUs assess their current CLABSI and CAUTI prevention efforts, has resources to help ICUs overcome common challenges in infection-reduction efforts, and provides the clinical and cultural guidance to make changes needed to decrease CLABSI and CAUTI rates.

  • Toolkit for Reducing CLABSI in Hospitals

    These tools were specifically developed to apply the CUSP method to prevent CLABSIs.

  • Toolkit for Reducing CAUTI in Hospitals

    This toolkit helps hospital units teach team members how to adopt and sustain best practices to improve safety culture and reduce CAUTI.

  • Toolkit To Improve Safety For Mechanically Ventilated Patients

    This toolkit helps hospitals make care safer for mechanically ventilated patients in intensive care units.

  • Toolkit To Promote Safe Surgery

    This toolkit helps surgical units improve safety culture and reduce surgical site infections and other complications.

  • Toolkit To Improve Safety in Ambulatory Surgery Centers

    This toolkit helps ambulatory surgery centers reduce surgical site infections and other complications.

  • Toolkit To Reduce CAUTI and Other HAIs in Long-Term Care Facilities

    This toolkit helps nursing homes and long-term-care facilities reduce catheter-associated urinary tract infection (CAUTI) and other HAIs.

  • ÂÜÀòÊÓƵSafety Program for MRSA Prevention

    This ongoing implementation project aims to help intensive care units, non-intensive care units, surgical services, and long-term care facilities measurably decrease invasive methicillin-resistant Staphylococcus aureus infections using the CUSP method.

Other Tools 

  • Toolkit for Decolonization of Non-ICU Patients With Devices

    This toolkit can help hospital infection prevention programs implement a decolonization protocol that was found to reduce bloodstream infections by roughly 30 percent in adult inpatients who were not in intensive care units and who had specific medical devices. It includes implementation instructions, demonstration videos, and customizable tools.

  • Community-Acquired Pneumonia Clinical Decision Support Implementation Toolkit

    This toolkit is a resource to help clinicians and clinical informaticians in primary care and other ambulatory settings implement and adopt the community-acquired pneumonia (CAP) clinical decision support (CDS) alert for the management of community-acquired pneumonia.

  • Universal ICU Decolonization: An Enhanced Protocol

    This protocol provides instructions for implementing universal decolonization in adult ICUs, as was done in the REDUCE MRSA Trial (New England Journal of Medicine, May 29, 2013).

  • This field-tested toolkit helps dialysis centers apply proven methods to reduce HAIs in this vulnerable patient population.

  • Nursing Home Antimicrobial Stewardship Guide

    This guide includes several toolkits and step-by-step guidance to help nursing homes implement an antibiotic stewardship program, determine if it’s necessary to treat a resident with antibiotics, help clinicians select the right antibiotic, and engage residents and families in infection prevention.

  • Central Line Insertion Care Team Checklist

    This checklist provides sequential critical steps that have shown to reduce central line-associated infections.

Resources

HAI and CARB Funding

Learn more about HAI and CARB funding.

Are you presenting an abstract about your HAI or CARB research at an upcoming HAI conference? If so, send the title of your abstract and information about the conference to patientsafety@ahrq.hhs.gov so we can help promote your work.

Page last reviewed April 2025
Page originally created September 2014

Internet Citation: AHRQ's Healthcare-Associated Infections Program. Content last reviewed April 2025. Agency for Healthcare Research and Quality, Rockville, MD.
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